This chapter examines several lives in the context of sexological theory and the rise of the binary homosexual/heterosexual model of desire. Psychologists pathologized previous models and patterns of same-sex relationships and focused on the sexually adventurous, dominating, “mannish” woman as the core prototype of the lesbian. At heart, these models revolved around “gender inversion” seeing the homosexual (male or female) as someone whose entire life and personality partook of a different gender than the one they were assigned at birth (to use the current terminology).